Renal Cell Cancer
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Clinical Features
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Investigations
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Management
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Prognosis
For patients with resectable disease, cure is possible. For patients with unresectable or recurrent and metastatic disease, renal cell cancer becomes a palliative illness. In recent years, with the advent of effective treatments such as sunitinib and sorafenib, people are living longer.
Some of the negative prognostic factors include:
- A poor performance score (AKPS of 70 or less)
- Biochemical abnormalities, including
- A raised LDH > 1.5 times normal
- A raised corrected calcium (> 2.5)
- A low haemoglobin (below the lower limit of normal)
- No previous nephrectomy (that is, locally advanced disease that could not be resected as opposed to recurrent disease post surgery)
Certain histological sub-types of renal cell cancer are associated with a poor prognosis too. Patients with sarcomatoid features generally have a poorer prognosis. In one study, approximately 20% of patients with this cancer had a partial response to treatment, 50% had a stable disease and 30% had progressive disease, with a overall median survival of 5 months.1)