[[renal_cell_cancer]]

This section is a stub and needs content added.

2019/07/08 14:03 · Graham Grove

This section is a stub and needs content added.

2019/07/08 14:03 · Graham Grove

This section is a stub and needs content added.

2019/07/08 14:03 · Graham Grove

Left renal cell cancer in a patient with increasing back pain Left renal cell cancer in a patient with increasing back pain

This section is a stub and needs content added.

2019/07/08 14:03 · Graham Grove

For patients with resectable disease, cure is possible. For patients with unresectable or recurrent and metastatic disease, renal cell cancer becomes a palliative illness. In recent years, with the advent of effective treatments such as sunitinib and sorafenib, people are living longer.

Some of the negative prognostic factors include:

  • A poor performance score (AKPS of 70 or less)
  • Biochemical abnormalities, including
  • A raised LDH > 1.5 times normal
  • A raised corrected calcium (> 2.5)
  • A low haemoglobin (below the lower limit of normal)
  • No previous nephrectomy (that is, locally advanced disease that could not be resected as opposed to recurrent disease post surgery)

Certain histological sub-types of renal cell cancer are associated with a poor prognosis too. Patients with sarcomatoid features generally have a poorer prognosis. In one study, approximately 20% of patients with this cancer had a partial response to treatment, 50% had a stable disease and 30% had progressive disease, with a overall median survival of 5 months.1)


1) ​​Golshayan et al. Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. Clin Oncol. 2009; 27(2):235.
  • renal_cell_cancer.txt
  • Last modified: 2019/07/09 23:23
  • by Graham Grove